I used to live in Manchester and travelled around the country a lot on business, including the M56/M6/M5 corridor more times than I care to remember.
You’ll get down to level with Bristol area on the M5 from Manchester in 3 – 3.5hrs outside rush hour and excluding major road works, once you’re on the M56, if you go a steady 65 – 70mph.
How long from there to Charles’ place I don’t know, but unlikely to be more than 30 mins from an M5 junction.